Rheumatoid arthritis (RA) is a chronic autoimmune disease that primarily affects the joints, causing inflammation, pain, and eventual damage. Unlike osteoarthritis, which is caused by the wear and tear of cartilage over time, rheumatoid arthritis results from the body’s immune system attacking healthy tissues, particularly the synovial membrane that lines the joints. This leads to joint inflammation and can eventually cause joint damage, loss of function, and disability if not properly managed.
As one of the most common forms of inflammatory arthritis, rheumatoid arthritis can have a significant impact on a person’s ability to perform everyday activities. In addition to joint-related symptoms, RA can affect other systems of the body, making it a systemic condition. Though there is no cure for rheumatoid arthritis, early diagnosis and a comprehensive treatment plan can help manage symptoms, slow disease progression, and improve the quality of life for individuals with RA. Worsening cases of rheumatoid arthritis may qualify as a serious health condition allowing for job protected medical leave under the FMLA.
Rheumatoid arthritis (RA) is an autoimmune disease in which the body’s immune system mistakenly attacks its own tissues, specifically the synovial membrane in the joints. This inflammation can spread to other areas, such as blood vessels and organs like the lungs and heart. Over time, chronic inflammation damages the joints and other affected areas, leading to painful joints, joint stiffness, and potential joint deformities.
The disease typically begins in smaller joints, such as the interphalangeal joints in the hands and feet, but can progress to affect larger joints, including the knee, elbow, and cervical spine. RA usually affects joints symmetrically, meaning it often impacts joints on both sides of the body, such as both wrists or both knees.
While RA is most commonly diagnosed in middle-aged adults, it can occur at any age and is more common in women than in men. The exact causes of rheumatoid arthritis are still not fully understood, but both genetic and environmental factors play a role in its development.
The primary cause of rheumatoid arthritis is an autoimmune response in which the immune system attacks the body’s own tissues. In people with RA, immune cells, including T cells, B cells, and dendritic cells, mistakenly target the synovial membrane (the lining of the joints) as if it were a foreign invader. This triggers an inflammatory response, leading to joint inflammation, pain, and damage.
As the disease progresses, chronic inflammation can damage the cartilage, ligaments, and even the bone. In advanced stages, this can lead to joint deformities and significant loss of function, affecting an individual’s ability to perform daily tasks.
Genetics plays a critical role in the development of rheumatoid arthritis. Individuals with a family history of RA are more likely to develop the condition themselves. Researchers have identified certain genes, including the HLA-DRB1 gene, that are associated with an increased risk of rheumatoid arthritis. These genes may influence how the immune system responds to triggers and contribute to autoimmune conditions.
While genetics increases susceptibility, not everyone with a genetic predisposition will develop RA. Environmental factors, such as smoking and infections, can also contribute to the onset of rheumatoid arthritis in genetically predisposed individuals.
Several environmental factors are believed to trigger the onset of rheumatoid arthritis in genetically predisposed individuals. One of the most significant is smoking, which is known to increase the risk of developing RA, especially in those with the genetic risk factors. Infections, such as bacterial or viral infections, may also contribute to the development of RA by triggering an abnormal immune response.
Other environmental triggers include stress, dietary factors, and exposure to certain chemicals or toxins. However, more research is needed to fully understand how these factors contribute to the development of RA.
The hallmark symptoms of rheumatoid arthritis are related to joint inflammation and include:
RA often begins in smaller joints, such as the fingers and toes, and gradually progresses to larger joints, like the wrists, elbows, knees, and hips. In severe cases, RA can cause joint deformities and loss of function.
Rheumatoid arthritis is a systemic disease, meaning it can affect more than just the joints. People with RA may experience symptoms outside of the joints, including:
Rheumatoid arthritis can affect people of all ages but is most commonly diagnosed in individuals between the ages of 30 and 60. Women are more likely than men to develop RA, with the ratio of women to men affected being roughly 3:1. This disparity may be due to hormonal differences, as estrogen may influence the immune system and contribute to the increased prevalence of RA in women.
Certain lifestyle factors can increase the risk of developing rheumatoid arthritis. Smoking is one of the most significant modifiable risk factors. People who smoke are at a higher risk of developing RA, and smoking can also worsen disease progression in those already diagnosed with the condition.
Obesity is another risk factor, as it can contribute to systemic inflammation and worsen symptoms of rheumatoid arthritis.
Having a family history of rheumatoid arthritis increases the risk of developing the disease. Specific genetic markers, such as the rheumatoid factor (RF), are associated with a higher likelihood of developing RA. While family history is a strong risk factor, many people with RA do not have a family history of the condition.
The diagnosis of rheumatoid arthritis begins with a thorough physical examination and medical history. A healthcare professional will assess the symptoms of rheumatoid arthritis, including joint stiffness, swelling, and pain. The doctor will typically examine the joints for signs of inflammation, deformities, and limitations in range of motion.
The physical exam will also focus on any other signs of systemic involvement, such as fever, fatigue, or swelling in non-joint areas. The physician will inquire about the patient’s family history, lifestyle factors, and symptom duration.
Several blood tests can help confirm the diagnosis of rheumatoid arthritis and assess disease activity. Common tests include:
X-rays, MRI, and ultrasound are used to evaluate joint damage and assess the extent of inflammation. Early in the disease, imaging tests may reveal joint swelling, changes in the synovial membrane, and joint space narrowing. In advanced stages, X-rays may show bony erosions or deformities that can help confirm the diagnosis.
The main goals of treatment for rheumatoid arthritis are to relieve symptoms, reduce inflammation, and prevent joint damage. The following medications are commonly used:
Managing rheumatoid arthritis often involves a combination of medication and lifestyle changes. These include:
Chronic inflammation caused by rheumatoid arthritis can lead to joint damage and disability. This damage can limit an individual’s ability to perform daily tasks and may require surgical interventions, such as joint replacement surgery.
Rheumatoid arthritis is associated with an increased risk of cardiovascular disease due to the systemic inflammation caused by the disease. People with RA are more likely to develop heart disease, stroke, and hypertension.
Living with rheumatoid arthritis requires ongoing management and support. It is essential to work closely with healthcare professionals, including rheumatologists, physical therapists, and occupational therapists, to develop a comprehensive treatment plan. Regular exercise, dietary changes, and the use of assistive devices can help individuals with RA lead an active and fulfilling life.
Living with rheumatoid arthritis requires ongoing management and support. It is essential to work closely with healthcare professionals, including rheumatologists, physical therapists, and occupational therapists, to develop a comprehensive treatment plan. Regular exercise, dietary changes, and the use of assistive devices can help individuals with RA lead an active and fulfilling life.
Rheumatoid arthritis can qualify for FMLA (Family and Medical Leave Act) leave if it meets the criteria for a serious health condition. Individuals with RA may require leave for:
Employees with RA can request FMLA leave to manage their condition and preserve their job security during periods of active disease or treatment.
Rheumatoid arthritis is a chronic autoimmune disease that can cause significant joint pain, inflammation, and disability. Although there is no cure for RA, early diagnosis and effective treatment options can help manage symptoms, slow disease progression, and improve the overall quality of life for those affected. By understanding the causes, symptoms, and treatment strategies for rheumatoid arthritis, individuals can take control of their health and continue to lead active, fulfilling lives despite the challenges posed by the disease.
If you are experiencing ongoing symptoms of rheumatoid arthritis that are affecting your job performance, you may qualify for FMLA leave on a continuous or intermittent basis. In addition, you may be eligible for workplace accommodations trough the Americans with Disabilities Act (ADA). Reach out to myFMLA for a physician consultation and assistance with FMLA certification, short term disability or ADA accommodations.
Copyright © 2025 myFMLA. All Rights Reserved. Powered by Ventnor Web Agency.
